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Article

Human monoclonal antibodies to SARS-coronavirus inhibit infection by different mechanisms.

Virology - 10 Nov 2009

Coughlin Melissa M, Babcook John, Prabhakar Bellur S

Abstract excerpt

SARS-CoV causes an acute infection making targeted passive immunotherapy an attractive treatment strategy. We previously generated human mAbs specific to the S1 region of SARS-CoV S protein. These mAbs bind epitopes within the receptor binding domain (RBD) or upstream of the RBD. We show that mAbs recognizing epitopes within the RBD inhibit infection by preventing viral attachment to the cellular receptor. One...

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Share to Antibodies, Viral
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19748648
DOI: 10.1016/j.virol.2009.07.028
PMCID: PMC7111986

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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