Article
Role of the GYVG pore motif of HslU ATPase in protein unfolding and translocation for degradation by HslV peptidase.
The Journal of biological chemistry - 17 Jun 2005
Park Eunyong, Rho Young Min, Koh Ohn-Jo, Ahn Sung Won, Seong Ihn Sik, Song Ji-Joon, Bang Oksun, Seol Jae Hong, Wang Jimin, Eom Soo Hyun, Chung Chin Ha
Abstract excerpt
HslVU is an ATP-dependent protease consisting of HslU ATPase and HslV peptidase. In an HslVU complex, the central pores of HslU hexamer and HslV dodecamer are aligned and the proteolytic active sites are sequestered in the inner chamber of HslV. Thus, the degradation of natively folded proteins requires unfolding and translocation processes for their access into the proteolytic chamber of HslV. A highly conserved...
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