Article
Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1997
Esnouf R M, Ren J, Hopkins A L, Ross C K, Jones E Y, Stammers D K, Stuart D I
Abstract excerpt
The viral reverse transcriptase (RT) provides an attractive target in the search for anti-HIV therapies. The nonnucleoside inhibitors (NNIs) are a diverse set of compounds (usually HIV-1 specific) that function by distorting the polymerase active site upon binding in a nearby pocket. Despite bein...
Topics
- Acquired Immunodeficiency Syndrome
- Anti-HIV Agents
- Delavirdine
- Drug Resistance, Microbial
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Indoles
- Molecular Sequence Data
- Mutation
- Piperazines
- Reverse Transcriptase Inhibitors