Article
Genomewide analysis of the host response to malaria in Kenyan children.
The Journal of infectious diseases - 15 May 2005
Griffiths Michael J, Shafi Mohammed J, Popper Stephen J, Hemingway Cheryl A, Kortok Moses M, Wathen Andrew, Rockett Kirk A, Mott Richard, Levin Michael, Newton Charles R, Marsh Kevin, Relman David A, Kwiatkowski Dominic P
Abstract excerpt
Malaria is a global problem, and there is a critical need for further understanding of the disease process. When malarial parasites invade and develop within the bloodstream, they stimulate a profound host response whose main clinical sign is fever. To explore this response, we measured host gene expression in whole blood from Kenyan children hospitalized with either acute malaria or other febrile illnesses....
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