Article
The C/C-13910 genotype of adult-type hypolactasia is associated with an increased risk of colorectal cancer in the Finnish population.
Gut - 1 May 2005
Rasinperä H, Forsblom C, Enattah N S, Halonen P, Salo K, Victorzon M, Mecklin J-P, Järvinen H, Enholm S, Sellick G, Alazzouzi H, Houlston R, Robinson J, Groop P-H, Tomlinson I, Schwartz S, Aaltonen L A, Järvelä I
Abstract excerpt
BACKGROUND AND AIMS: The role of nutrition in the pathogenesis of colorectal cancer is not fully understood. Milk products are an essential part of human nutrition in Western countries. Absorption of lactose, the main sugar of milk, is regulated by the activity of the lactase enzyme in the gut wall. The activity of lactase is genetically determined and is associated with a C/T single nucleotide polymorphism...
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