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Article

Small-interfering RNA–induced androgen receptor silencing leads to apoptotic cell death in prostate cancer

1 Apr 2005

Abstract excerpt

Prostate cancer is the second leading cause of cancer death in the United States and, thus far, there has been no effective therapy for the treatment of hormone-refractory disease. Recently, the androgen receptor (AR) has been shown to play a critical role in the development and progression of the disease. In this report, we showed that knocking down the AR protein level by a small interfering RNA (siRNA)...

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PMID: 15827323
DOI: 10.1158/1535-7163.mct-04-0313

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