Article
Relative atrophy of the flocculus and ocular motor dysfunction in SCA2 and SCA6.
Annals of the New York Academy of Sciences - 1 Apr 2005
Ying S H, Choi S I, Lee M, Perlman S L, Baloh R W, Toga A W, Zee D S
Abstract excerpt
Two hereditary ataxia syndromes show distinct profiles of region-specific atrophy and ocular motor deficits. Selective pontine atrophy is associated with slowed saccades in ataxin-2 mutations, and selective floccular atrophy is associated with impaired pursuit and gaze-holding abnormalities in Ca(V)2.1 mutations. Although the flocculus seems to be spared relative to the pons in ataxin-2 mutations, and pursuit and...
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