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Article

The ocular motor features of adult-onset alexander disease: a case and review of the literature.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society - 1 Jun 2011

Pfeffer Gerald, Abegg Mathias, Vertinsky A Talia, Ceccherini Isabella, Caroli Francesco, Barton Jason J S

Abstract excerpt

A 51-year-old Chinese man presented with gaze-evoked nystagmus, impaired smooth pursuit and vestibular ocular reflex cancellation, and saccadic dysmetria, along with a family history suggestive of late-onset autosomal dominant parkinsonism. MRI revealed abnormalities of the medulla and cervical spinal cord typical of adult-onset Alexander disease, and genetic testing showed homozygosity for the p.D295N...

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PMID: 21403579
DOI: 10.1097/WNO.0b013e31820ecb28

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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