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A Systematic Analysis on DNA Methylation and the Expression of Both mRNA and microRNA in Bladder Cancer

30 Nov 2011

Abstract excerpt

BACKGROUND: DNA methylation aberration and microRNA (miRNA) deregulation have been observed in many types of cancers. A systematic study of methylome and transcriptome in bladder urothelial carcinoma has never been reported. METHODOLOGY/PRINCIPAL FINDINGS: The DNA methylation was profiled by modified methylation-specific digital karyotyping (MMSDK) and the expression of mRNAs and miRNAs was analyzed by digital...

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PMID: 22140553
DOI: 10.1371/journal.pone.0028223

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