Article
Recent advances in paroxysmal nocturnal hemoglobinuria. From the biology to the clinic.
Hematology and cell therapy - 1 Aug 1997
Socié G
Abstract excerpt
PNH is now known as an acquired, clonal disorder of the hematopoetic stem cells caused by somatic mutation in the X-linked PIG-A gene encoding a protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) anchor by which many proteins are attached to the membrane. Since the past few years, significant advances in the knowledge of the biology of this rare disease have been done. Similarly on the...
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