Article
Identification of a novel A2 allele derived from the A transferase gene through a nucleotide substitution G539C.
Vox sanguinis - 1 Apr 2005
Chen D-P, Tseng C-P, Wang W-T, Sun C-F
Abstract excerpt
BACKGROUND AND OBJECTIVES: The A2 is a very rare phenotype in the ABO blood group system in the Oriental population. It corresponds to a special ABO allele encoding a glycosyltransferase that is capable of synthesizing A2 antigens, which is weaker than the typical A antigen. In this study, we report a novel A2 allele in two unrelated Taiwanese individuals. MATERIALS AND METHODS: Two individuals were identified as...
Topics
- ABO Blood-Group System
- Alleles
- Base Sequence
- Cloning, Molecular
- DNA Primers
- Fucosyl Galactose alpha-N-Acetylgalactosaminyltransferase
- Glycosyltransferases
- Humans
- Molecular Sequence Data
- Mutation
- Phenotype
- Point Mutation
- Polymerase Chain Reaction
- Sequence Analysis, DNA
- Taiwan
- Transferases