Article
Infrequent mutation of the human envoplakin gene is closely linked to the tylosis oesophageal cancer locus in sporadic oesophageal squamous cell carcinomas.
Oncology reports - 1 Apr 2005
Iwaya Takeshi, Maesawa Chihaya, Kimura Toshimoto, Ogasawara Satoshi, Ikeda Kenichro, Kimura Yusuke, Noda Yoshinori, Ishida Kaoru, Sato Nobuhiro, Saito Kazuyoshi, Masuda Tomoyuki
Abstract excerpt
Envoplakin (EVPL) is a member of the desmosomal plaque proteins attached to desmosomal cadherin and keratin filaments. The EVPL gene has been mapped to the tylosis oesophageal cancer (TOC) locus on chromosome 17q25, where it has been demonstrated to be frequently deleted in both familial and sporadic forms of oesophageal squamous cell carcinoma (OSC). In this study, we examined EVPL gene mutations in 10 OSC cell...
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