Article
Novel microsatellite markers and single nucleotide polymorphisms refine the tylosis with oesophageal cancer (TOC) minimal region on 17q25 to 42.5 kb: sequencing does not identify the causative gene.
Human genetics - 1 May 2004
Langan Joanne E, Cole Charlotte G, Huckle Elisabeth J, Byrne Shaun, McRonald Fiona E, Rowbottom Lynn, Ellis Anthony, Shaw Joan M, Leigh Irene M, Kelsell David P, Dunham Ian, Field John K, Risk Janet M
Abstract excerpt
Tylosis (focal non-epidermolytic palmoplantar keratoderma) is associated with the early onset of squamous cell oesophageal cancer in three families. Linkage and haplotype analyses have previously mapped the tylosis with oesophageal cancer ( TOC) locus to a 500-kb region on chromosome 17q25 that has also been implicated in sporadically occurring squamous cell oesophageal cancer. In the current study, 17 additional...
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