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Article

Nuclear localization of HTLV-I bZIP factor (HBZ) is mediated by three distinct motifs.

Journal of cell science - 1 Apr 2005

Hivin Patrick, Frédéric Mélissa, Arpin-André Charlotte, Basbous Jihane, Gay Bernard, Thébault Sabine, Mesnard Jean-Michel

Abstract excerpt

The genome of the human T-cell leukemia virus type I (HTLV-I) codes for a basic leucine zipper protein, HBZ, capable of repressing JUN activity and viral transcription. Transient expression in mammalian cells showed that HBZ was targeted to the nucleus, where it accumulated in nuclear speckles. By using a complementary set of deletion mutants, we report here that the nuclear targeting of HBZ is mediated by three...

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Source

Identifiers

PMID: 15755797
DOI: 10.1242/jcs.01727

Genes

HBZ
JUN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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