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Article

Perforin and lymphohistiocytic proliferative disorders.

British journal of haematology - 1 Mar 2005

Katano Harutaka, Cohen Jeffrey I

Abstract excerpt

Perforin is critical for cytotoxicity mediated by granules present in natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). Perforin-deficient mice have impaired cytotoxicity by NK cells and CTLs, resulting in failure to control infections with certain viruses or bacteria. Infection of perforin-deficient mice with lymphocytic choriomeningitis virus results in haemophagocytic lymphohistiocytosis and...

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Identifiers

PMID: 15755277
DOI: 10.1111/j.1365-2141.2004.05305.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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