Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evaluation of host immune responses to pulmonary cryptococcosis using a temperature-sensitive C. neoformans calcineurin A mutant strain.

Microbial pathogenesis - 1 Jan 2000

Wormley Floyd L, Cox Gary M, Perfect John R

Abstract excerpt

Cryptococcus neoformans is an opportunistic fungal pathogen that threatens individuals with impaired cell-mediated immunity (CMI). Presently, there are no standardized vaccines available to prevent cryptococcal infections and conventional anti-fungal drug therapy does not induce host immune reactivity and thus cannot efficiently resolve C. neoformans infections in immunocompromised individuals. The present study...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcineurin
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemokine CCL2

Share to Cryptococcosis

Share to Cryptococcus neoformans

Share to Immunity, Cellular

Share to Interleukin-4

Share to Vaccines, Attenuated

Source

Identifiers

PMID: 15748813
DOI: 10.1016/j.micpath.2004.12.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluation of host immune responses to pulmonary cryptococcosis using a temperature-sensitive C. neoformans calcineurin A mutant strain.PMID 15748813Read ↗

Cryptococcus neoformans requires the TVF1 gene for thermotolerance and virulenceSemantic proximity Read ↗

Virulence factors identified by Cryptococcus neoformans mutant screen differentially modulate lung immune responses and brain dissemination.Semantic proximity Read ↗

Cryptococcus neoformans trehalose-6-phosphate synthase (tps1) promotes organ-specific virulence and fungal protection against multiple lines of host defensesSemantic proximity Read ↗

A Heat-Killed Cryptococcus Mutant Strain Induces Host Protection against Multiple Invasive Mycoses in a Murine Vaccine ModelSemantic proximity Read ↗

Induction of Protective Immunity to Cryptococcal Infection in Mice by a Heat-Killed, Chitosan-Deficient Strain of Cryptococcus neoformans.Semantic proximity Read ↗

Organ-specific immune responses are strain-dependent in a mouse model of <i>Cryptococcus neoformans</i> brain infectionSemantic proximity Read ↗

Identification of ENA1 as a Virulence Gene of the Human Pathogenic Fungus Cryptococcus neoformans through Signature-Tagged Insertional MutagenesisSemantic proximity Read ↗

Lack of an atypical PDR transporter generates an immunogenic <i>Cryptococcus neoformans</i> strain that drives a dysregulated and lethal immune response in murine lungsSemantic proximity Read ↗

Cryptococcal Interactions with the Host Immune SystemSemantic proximity Read ↗

Had1 Is Required for Cell Wall Integrity and Fungal Virulence in Cryptococcus neoformans.Semantic proximity Read ↗

The F-Box Protein Fbp1 Shapes the Immunogenic Potential of Cryptococcus neoformansSemantic proximity Read ↗

A hyper-immunogenic and slow-growing fungal strain induces a murine granulomatous response to cryptococcal infectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.