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Article

Beta-lactam screening by specific residues of the OmpF eyelet.

Journal of medicinal chemistry - 10 Mar 2005

Vidal Stéphanie, Bredin Jérôme, Pagès Jean-Marie, Barbe Jacques

Abstract excerpt

Beta-lactams use aqueous channels of porins to penetrate Gram-negative bacteria. The L3 loop of Escherichia coli OmpF porin is a key feature that actively contributes to both channel size and electrostatic properties. Acid residues D113, E117, and D121 are responsible for the negative part of the local electrostatic field on this loop. Two substitutions, D113A and D121A, located in the negatively charged cluster...

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Identifiers

PMID: 15743183
DOI: 10.1021/jm049652e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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