Article
Mutations in feline immunodeficiency (FIV) virus envelope gene V3-V5 regions in FIV-infected cats.
Veterinary microbiology - 20 Mar 2005
Motokawa Kenji, Hohdatsu Tsutomu, Imori Aya, Arai Setsuo, Koyama Hiroyuki
Abstract excerpt
The envelope (Env) gene V3-V5 regions of the feline immunodeficiency virus (FIV) encode the neutralizing epitopes. Since mutations in these regions induce resistance to viral neutralizing antibodies, they may influence the effects of vaccines. To examine the in vivo mutation rate in these regions, we cloned cDNA for the Env gene V3-V5 regions from the PBMC of experimentally FIV-infected cats, and compared the...
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