Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ectopic expression of KitD814Y in spermatids of transgenic mice, interferes with sperm morphogenesis.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 May 2005

Schnabel Denhí, Ramírez Laura, Gertsenstein Marina, Nagy Andras, Lomelí Hilda

Abstract excerpt

Kit is a receptor tyrosine kinase that plays a fundamental role during the development of germ cells. Additionally, a truncated product, tr-kit, expressed in haploid spermatids and mature spermatozoa can induce parthenogenetic activation when microinjected into mouse eggs, through the activation of PLCgamma-1. In this work, we induced ectopic expression of a mutated Kit protein, Kit(D814Y) during germ cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Infertility, Male
Share to Integrases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phospholipase C gamma

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 6

Share to Spermatids

Share to Spermatogenesis

Share to Spermatozoa

Share to Type C Phospholipases

Source

Identifiers

PMID: 15736269
DOI: 10.1002/dvdy.20292

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Ectopic expression of KitD814Y in spermatids of transgenic mice, interferes with sperm morphogenesis.PMID 15736269Read ↗

Isolation and characterization of the spermatid-specific Smrp1 gene encoding a novel manchette protein.Semantic proximity Read ↗

Bypassing natural sperm selection during fertilization: the azh mutant offspring experience and the alternative of spermiogenesis in vitro.Semantic proximity Read ↗

Spermiogenesis Is Impaired in Mice Bearing a Targeted Mutation in the Protein Phosphatase 1cγ GeneSemantic proximity Read ↗

Retention of gene products in syncytial spermatids promotes non-Mendelian inheritance as revealed by the t complex responder.Semantic proximity Read ↗

E-MAP-115, encoding a microtubule-associated protein, is a retinoic acid-inducible gene required for spermatogenesis.Semantic proximity Read ↗

Latrunculin A Can Improve the Birth Rate of Cloned Mice and Simplify the Nuclear Transfer Protocol by Gently Inhibiting Actin Polymerization1Semantic proximity Read ↗

γ-Tubulin reorganization during mouse fertilization and early developmentSemantic proximity Read ↗

Association of cytoplasmic dynein with manchette microtubules and spermatid nuclear envelope during spermiogenesis in ratsSemantic proximity Read ↗

A cell- and developmental stage-specific promoter drives the expression of a truncated c-kit protein during mouse spermatid elongationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.