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A comparative study of oxidative DNA damage in mammalian spermatozoa

1 Jan 2005

Abstract excerpt

Alkaline gel electrophoresis, pulsed field gel electrophoresis, and quantitative PCR analyses (QPCR) of the nuclear (nDNA) and mitochondrial (mtDNA) genomes were used to assess DNA integrity in the spermatozoa of three species exposed to oxidative stress. In human and murine spermatozoa, the mtDNA was significantly more susceptible to H2O2-mediated damage than nDNA. In both eutherian species, exposure to 250...

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PMID: 15736137
DOI: 10.1002/mrd.20285

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