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Article

Relative Impact of Oxidative Stress on the Functional Competence and Genomic Integrity of Human Spermatozoa1

1 Nov 1998

Abstract excerpt

Reactive oxygen metabolites are known to disrupt sperm-oocyte fusion, sperm movement, and DNA integrity; however, the relative sensitivities of these elements to oxidative stress are unknown. In this study these factors were assessed in human spermatozoa exposed to increasing levels of oxidative stress achieved through the stimulation of endogenous oxidant generation with NADPH or direct exposure to hydrogen...

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PMID: 9780307
DOI: 10.1095/biolreprod59.5.1037

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