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Paternal impacts on development: identification of genomic regions vulnerable to oxidative DNA damage in human spermatozoa

12 Jul 2019

Abstract excerpt

STUDY QUESTION: Do all regions of the paternal genome within the gamete display equivalent vulnerability to oxidative DNA damage? SUMMARY ANSWER: Oxidative DNA damage is not randomly distributed in mature human spermatozoa but is instead targeted, with particular chromosomes being especially vulnerable to oxidative stress. WHAT IS KNOWN ALREADY: Oxidative DNA damage is frequently encountered in the spermatozoa of...

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PMID: 31593593
DOI: 10.1093/humrep/dez153

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