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Article

Parkinsonism following neuroleptic exposure: A double-hit hypothesis?

Movement disorders : official journal of the Movement Disorder Society - 1 May 2015

Erro Roberto, Bhatia Kailash P, Tinazzi Michele

Abstract excerpt

Drug-induced parkinsonism is caused by an offending drug and should resolve after the causative agent has been withdrawn. However, in a number of patients, symptoms persist or may even worsen over time, suggesting the development of concomitant Parkinson's disease. The prevalence estimates of Parkinson's disease after neuroleptic exposure are unexpectedly high, suggesting a causal relationship. We critically...

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PMID: 25801826
DOI: 10.1002/mds.26209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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