Article
Functional consequences of polyamine synthesis inhibition by L-alpha-difluoromethylornithine (DFMO): cellular mechanisms for DFMO-mediated ototoxicity.
The Journal of biological chemistry - 15 Apr 2005
Nie Liping, Feng Weihong, Diaz Rodney, Gratton Michael A, Doyle Karen Jo, Yamoah Ebenezer N
Abstract excerpt
L-Alpha-difluoromethylornithine (DFMO) is a chemopreventive agent for colon cancer in clinical trials. Yet, the drug produces an across-frequency elevation of the hearing threshold, suggesting that DFMO may affect a common trait along the cochlear spiral. The mechanism for the ototoxic effects of DFMO remains uncertain. The cochlear duct is exclusively endowed with endocochlear potential (EP). EP is a requisite...
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