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Article

Engineering the substrate specificity of xylose isomerase.

Protein engineering, design & selection : PEDS - 1 Dec 2004

Karimäki Johanna, Parkkinen Tarja, Santa Harri, Pastinen Ossi, Leisola Matti, Rouvinen Juha, Turunen Ossi

Abstract excerpt

Xylose isomerase (XI) catalyzes the isomerization and epimerization of hexoses, pentoses and tetroses. In order to clarify the reasons for the low reaction efficiency of a pentose sugar, L-arabinose, we determined the crystal structure of Streptomyces rubiginosus XI complexed with L-arabinose. The crystal structure revealed that, when compared with D-xylose and D-glucose, L-arabinose binds to the active site in a...

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PMID: 15713782
DOI: 10.1093/protein/gzh099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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