Backward simulation of ancestors of sampled individuals.

Abstract excerpt

If the population is large and the sampling mechanism is random, the coalescent is commonly used to model the haplotypes in the sample. Ordered genotypes can then be formed by random matching of the derived haplotypes. However, this approach is not realistic when (1) there is departure from random mating (e.g., dominant individuals in breeding populations or monogamy in humans), or (2) the population is small...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Haplotypes
• Share to Genetics, Population
• Share to Models, Statistical