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Article

Methylation of the gamma-catenin gene is associated with poor prognosis of renal cell carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2005

Breault Julia E, Shiina Hiroaki, Igawa Mikio, Ribeiro-Filho Leopoldo A, Deguchi Masao, Enokida Hideki, Urakami Shinji, Terashima Masaharu, Nakagawa Masayuki, Kane Christopher J, Carroll Peter R, Dahiya Rajvir

Abstract excerpt

PURPOSE: Gamma-catenin is a cell adhesion protein, and its functional loss is associated with tumor invasion and metastasis. We hypothesize that (1) promoter CpG methylation regulates the expression and function of the gamma-catenin gene in renal cell carcinoma (RCC) and (2) methylation of the gamma-catenin gene is associated with poor prognosis of RCC. To test these hypotheses, we analyzed the CpG methylation...

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PMID: 15701841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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