Article
GSPalpha mutations in Mexican patients with acromegaly: potential impact on long term prognosis.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 1 Feb 2005
Mendoza Victoria, Sosa Ernesto, Espinosa-de-Los-Monteros Ana Laura, Salcedo Mauricio, Guinto Gerardo, Cheng Sonia, Sandoval Carolina, Mercado Moises
Abstract excerpt
OBJECTIVE: The frequency of activating mutations of the GSPalpha gene as the etiology of GH-secreting pituitary adenomas has been the subject of important ethnogenetic variability. Whereas up to 40% of Caucasian patients with acromegaly have tumors which harbor these somatic mutations, their prevalence among Asian populations is much lower. The correlation between the presence of these mutations and the clinical...
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