Article
Variants in the Wilms' tumor gene are associated with focal segmental glomerulosclerosis in the African American population.
Physiological genomics - 14 Apr 2005
Orloff Mohammed S, Iyengar Sudha K, Winkler Cheryl A, Goddard Katrina A B, Dart Richard A, Ahuja Tejinder S, Mokrzycki Michele, Briggs William A, Korbet Stephen M, Kimmel Paul L, Simon Eric E, Trachtman Howard, Vlahov David, Michel Donna M, Berns Jeffrey S, Smith Michael C, Schelling Jeffrey R, Sedor John R, Kopp Jeffrey B
Abstract excerpt
Wilms' tumor gene (WT1) is important for nephrogenesis and gonadal growth. WT1 mutations cause Denys-Drash and Frasier syndromes, which are characterized by glomerular scarring. To test whether genetic variations in WT1 and WIT1 (gene immediately 5' to WT1) associate with focal segmental glomerulosclerosis (FSGS), patients with biopsy-proven idiopathic and HIV-1-associated FSGS were enrolled in a multicenter...
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