Article
Drosophila couch potato mutants exhibit complex neurological abnormalities including epilepsy phenotypes.
Genetics - 1 Apr 2005
Glasscock Edward, Tanouye Mark A
Abstract excerpt
RNA-binding proteins play critical roles in regulation of gene expression, and impairment can have severe phenotypic consequences on nervous system function. We report here the discovery of several complex neurological phenotypes associated with mutations of couch potato (cpo), which encodes a Drosophila RNA-binding protein. We show that mutation of cpo leads to bang-sensitive paralysis, seizure susceptibility,...
Topics
- Alleles
- Animals
- Base Sequence
- Behavior, Animal
- Chromosome Mapping
- Crosses, Genetic
- Drosophila Proteins
- Electrochemistry
- Electrophysiology
- Electroshock
- Embryo, Nonmammalian
- Enhancer Elements, Genetic
- Epilepsy
- Female