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Regulated degradation of chromosome replication proteins DnaA and CtrA in Caulobacter crescentus.

Molecular microbiology - 1 Feb 2005

Gorbatyuk Boris, Marczynski Gregory T

Abstract excerpt

DnaA protein binds bacterial replication origins and it initiates chromosome replication. The Caulobacter crescentus DnaA also initiates chromosome replication and the C. crescentus response regulator CtrA represses chromosome replication. CtrA proteolysis by ClpXP helps restrict chromosome replication to the dividing cell type. We report that C. crescentus DnaA protein is also selectively targeted for...

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PMID: 15686567
DOI: 10.1111/j.1365-2958.2004.04459.x

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