Article
Genetic association of vitamin D receptor polymorphisms with autoimmune hepatitis and primary biliary cirrhosis in the Chinese.
Journal of gastroenterology and hepatology - 1 Feb 2005
Fan Lieying, Tu Xiaoqing, Zhu Ye, Zhou Lin, Pfeiffer Thomas, Feltens Ralph, Stoecker Winfried, Zhong Renqian
Abstract excerpt
BACKGROUND: Autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) are two autoimmune diseases of unknown etiology. Genetic factors appear to be involved in the pathogenesis of both diseases. Vitamin D has been shown to exert multiple immunomodulatory effects, which acts through its own receptor (VDR). Polymorphisms of VDR had been implicated in several autoimmune diseases. In the present study, the...
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