Article
A novel microdeletion syndrome with loss of the MSH2 locus and hereditary non‐polyposis colorectal cancer
7 Dec 2004
Abstract excerpt
Constitutional chromosome deletions can predispose to the development of cancer with the phenotypic characteristics of inherited cancer syndromes, when the deleted region encompasses a tumour suppressor gene. Examples of such conditions are represented by the cytogenetic deletions associated with retinoblastoma, Wilms tumour and familial adenomatous polyposis. So far, no constitutional deletions involving the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.