Neurofibromatosis and early onset of cancers in hMLH1-deficient children.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Neurofibromatosis and early onset of cancers in hMLH1-deficient children.

Cancer research - 15 Jan 1999

Wang Q, Lasset C, Desseigne F, Frappaz D, Bergeron C, Navarro C, Ruano E, Puisieux A

Abstract excerpt

Hereditary nonpolyposis colon cancer is a common hereditary disorder caused by the germ-line mutations of DNA mismatch repair (MMR) genes, especially hMLH1 and hMSH2. We report here the first identification of human compounds with a homozygous inactivation of a MMR gene. In a typical hereditary n...

Topics

Adaptor Proteins, Signal Transducing
Carrier Proteins
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA
DNA Repair
Female
Genes, Neurofibromatosis 1
Genetic Predisposition to Disease
Germ-Line Mutation
Humans
Male
MutL Protein Homolog 1
Neoplasm Proteins
Neurofibromatosis 1
Nuclear Proteins

Source

Open in PubMed

Identifiers

PMID: 9927034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9927034-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics