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Article

The effective molarity of the substrate phosphoryl group in the transition state for yeast OMP decarboxylase.

Bioorganic chemistry - 1 Feb 2005

Sievers Annette, Wolfenden Richard

Abstract excerpt

The second order rate constant (k(cat)/K(m)) for decarboxylation of orotidine by yeast OMP decarboxylase (ODCase), measured by trapping (14)CO(2) released during the reaction, is 2 x 10(-4)M(-1)s(-1). This very low activity may be compared with a value of 3 x 10(7)M(-1)s(-1) for the action of yeast OMP decarboxylase on the normal substrate OMP. Both activities are strongly inhibited by 6-hydroxy UMP (BMP), and...

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Source

Identifiers

PMID: 15668182
DOI: 10.1016/j.bioorg.2004.08.005

Genes

OMP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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