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A Type IV Pilin, PilA, Contributes to Adherence of<i>Burkholderia pseudomallei</i>and Virulence In Vivo

21 Jan 2005

Abstract excerpt

The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 15664977
DOI: 10.1128/iai.73.2.1260-1264.2005

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