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Loss of DNA Mismatch Repair Proteins in Skin Tumors From Patients With Muir–Torre Syndrome and MSH2 or MLH1 Germline Mutations

1 Mar 2002

Abstract excerpt

Muir-Torre syndrome (MTS) is a rare autosomal-dominant disorder characterized by the predisposition to both sebaceous skin tumors (or multiple keratoacanthomas) and internal malignancies. A subtype of MTS is allelic to hereditary nonpolyposis colorectal cancer and is caused by germline mutations in the DNA mismatch repair genes MSH2 or MLH1. In these cases both internal and skin tumors show characteristic...

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PMID: 11859205
DOI: 10.1097/00000478-200203000-00007

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