Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Abnormal mesenchymal differentiation in the superior semicircular canal of brn4/pou3f4 knockout mice.

Archives of otolaryngology--head & neck surgery - 1 Jan 2005

Sobol Steven E, Teng Xiuyin, Crenshaw E Bryan

Abstract excerpt

OBJECTIVE: To examine the developmental time course of the mutant phenotype and cellular mechanisms that result in malformations of the superior semicircular canal (SSCC) in Brn4 knockout mice. Mutations in the Brn4/Pou3f4 gene result in characteristic inner ear abnormalities in mutant mouse pedigrees, and the findings in these mice are similar to those in human X-linked deafness type III. DESIGN: Mutant and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Binding Proteins
Share to Mesoderm
Share to Mice, Knockout

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Animal

Share to Nerve Tissue Proteins

Share to Organogenesis

Share to POU Domain Factors

Share to Time Factors

Source

Identifiers

PMID: 15655183
DOI: 10.1001/archotol.131.1.41

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abnormal mesenchymal differentiation in the superior semicircular canal of brn4/pou3f4 knockout mice.PMID 15655183Read ↗

Mutation of the POU-domain gene Brn4/Pou3f4 affects middle-ear sound conduction in the mouse.Semantic proximity Read ↗

Deletion of and Novel Missense Mutation in POU3F4 in 2 Families Segregating X-Linked Nonsyndromic DeafnessSemantic proximity Read ↗

Defects in middle ear cavitation cause conductive hearing loss in the Tcof1 mutant mouse.Semantic proximity Read ↗

Hush puppy: a new mouse mutant with pinna, ossicle, and inner ear defects.Semantic proximity Read ↗

Asymmetry in semicircular canal diameters may account for circling behavior in EphB-deficient mice.Semantic proximity Read ↗

<i>Smed-pou4-2</i> regulates mechanosensory neuron regeneration and function in planariansSemantic proximity Read ↗

Prickle1 is necessary for the caudal migration of murine facial branchiomotor neurons.Semantic proximity Read ↗

Identification of cis-element regulating expression of the mouse Fgf10 gene during inner ear development.Semantic proximity Read ↗

Foxg1 is required for morphogenesis and histogenesis of the mammalian inner ear.Semantic proximity Read ↗

The role of bone morphogenetic protein 4 in inner ear development and function.Semantic proximity Read ↗

Requirement for Lmo4 in the vestibular morphogenesis of mouse inner ear.Semantic proximity Read ↗

The Wheels mutation in the mouse causes vascular, hindbrain, and inner ear defects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.