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Article

Anticonvulsant medications extend worm life-span.

Science (New York, N.Y.) - 14 Jan 2005

Evason Kimberley, Huang Cheng, Yamben Idella, Covey Douglas F, Kornfeld Kerry

Abstract excerpt

Genetic studies have elucidated mechanisms that regulate aging, but there has been little progress in identifying drugs that delay aging. Here, we report that ethosuximide, trimethadione, and 3,3-diethyl-2-pyrrolidinone increase mean and maximum life-span of Caenorhabditis elegans and delay age-related declines of physiological processes, indicating that these compounds retard the aging process. These compounds,...

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PMID: 15653505
DOI: 10.1126/science.1105299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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