Article
[Functional polymorphism of p53 and CCR5 genes in the long-lived of the Siberian region].
Vestnik Rossiiskoi akademii meditsinskikh nauk - 1 Jan 2004
Smetannikova M A, Beliavskaia V A, Smetannikova N A, Savkin I V, Denisova D V, Ustinov S N, Maksimov V N, Shabalin A V, Bolotnova T V, Voevoda M I
Abstract excerpt
The P53 protein is a key regulator of modified-cell apoptosis. The functional oligonucleotide polymorphism of the p53 gene causes the substitution of arginine (Arg) for praline (Pro) in the codon 72. A reduced apoptotic activity of p53 and, as a consequence, development of oncology pathology is associated with the above polymorphism. CCR5 is a compound transmembrane receptor-protein, which apart from chemokines,...
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