Article
Influence of beta3 integrin gene Leu/Pro33 polymorphism on primary glomerulonephritis.
Nephron. Experimental nephrology - 1 Jan 2005
Bantis Christos, Heering Peter J, Aker Sendogan, Kuhr Nicola, Grabensee Bernd, Ivens Katrin
Abstract excerpt
BACKGROUND: Beta3 integrin subunit is expressed as alpha(IIb)beta3 integrin on platelets and as alpha(v)beta3 integrin on a variety of cells including renal endothelial, mesangial and tubular cells. Leu33/Pro33 polymorphism of beta3 integrin has been associated with altered platelet functions, cardiovascular complications and the incidence of acute rejection episodes in renal transplantation. We investigated its...
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