Article
Genotyping the -6A/G functional polymorphism in the core promoter region of angiotensinogen gene by microchip electrophoresis.
Electrophoresis - 1 Jan 2005
Qin Jianhua, Liu Zhaoyi, Wu Dapeng, Zhu Ning, Zhou Xiaomian, Fung Yingsing, Lin Bingcheng
Abstract excerpt
Angiotensinogen (AGT) gene has been regarded as one of the candidate genes for essential hypertension. In our study, the role of AGT gene as a putatively predisposing gene for hypertension was evaluated by genotyping a A (-6) G polymorphism in the core promoter region in 123 patients with essential hypertension and 103 healthy controls. A microchip electrophoresis method coupled with polymorphism chain reaction...
Topics
- Aged
- Angiotensinogen
- China
- Electrophoresis, Microchip
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Hypertension
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length