Article
Phenotypic changes of p53, HER2, and FAS system in multiple normal tissues surrounding breast cancer.
Journal of cellular physiology - 1 Jul 2005
Mottolese Marcella, Nádasi Edit A, Botti Claudio, Cianciulli Anna M, Merola Roberta, Buglioni Simonetta, Benevolo Maria, Giannarelli Diana, Marandino Ferdinando, Donnorso Raffaele Perrone, Venturo Irene, Natali Pier Giorgio
Abstract excerpt
To determine whether phenotypic field changes occur in tissues adjacent to carcinoma, we assayed, by immunohistochemistry, the expression of HER-2, p53, Fas, and FasL in 72 breast cancers (BC) and multiple autologous peritumoral tissues (PTTs) sampled up to 5 cm distance and in 44 benign breast tumors (BBTs). About 5% and 3% of the PTTs and 4.5% and 6.8% of BBTs showed alterations in HER2 and p53 expression,...
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