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Article

Ascorbate restores lifespan of superoxide-dismutase deficient yeast.

Free radical research - 1 Sept 2004

Krzepiłko Anna, Swieciło Agata, Wawryn Jarosław, Zadrag Renata, Kozioł Sabina, Bartosz Grzegorz, Biliński Tomasz

Abstract excerpt

Yeast (Saccharomyces cerevisiae) mutants lacking CuZn-superoxide dismutase (CuZnSOD) are hypersensitive to oxygen and have significantly decreased replicative life span. Both these defects can be ameliorated by exogenous ascorbate. The effect of ascorbate on life span is complicated by auto-oxidation of its compound in the medium. If negative effects of auto-oxidation are prevented by exchange of the medium,...

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Identifiers

PMID: 15621721
DOI: 10.1080/10715760410001717327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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