Article
Role for rpoS gene of Pseudomonas aeruginosa in antibiotic tolerance.
FEMS microbiology letters - 1 Jan 2005
Murakami Keiji, Ono Tsuneko, Viducic Darija, Kayama Shizuo, Mori Makiko, Hirota Katsuhiko, Nemoto Ken, Miyake Yoichiro
Abstract excerpt
The alternative sigma factor, RpoS has been described as a central regulator of many stationary phase-inducible genes and a master stress-response regulator under various stress conditions. We constructed an rpoS mutant in Pseudomonas aeruginosa and investigated the role of rpoS gene in antibiotic tolerance. The survival of the rpoS mutant cells in stationary phase was approximately 70 times lower when compared...
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