Article
Regulation of tau exon 10 splicing by a double stem-loop structure in mouse intron 10.
FEBS letters - 3 Jan 2005
Yamashita Takenari, Tomiyama Takami, Li Qiang, Numata Hideharu, Mori Hiroshi
Abstract excerpt
Tau exon 10 (E10) splicing is a crucial event in its developmental change of tau isoform and tauopathy. To investigate the splicing mechanism, we isolated and compared mouse tau genomic sequence with human sequence. We identified a new element in mouse intron 10 (I10) to suppress E10 splicing, which was located just after the stem-loop region previously proposed in human sequence and found to potentially form...
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