Article
Towards a mutant map of the mouse--new models of neurological, behavioural, deafness, bone, renal and blood disorders.
Genetica - 1 Sept 2004
Rastan Sohaila, Hough Tertius, Kierman Amy, Hardisty Rachel, Erven Alexandra, Gray Ian C, Voeling Stepanie, Isaacs Adrian, Tsai Hsun, Strivens Mark, Washbourne Rebecca, Thornton Claire, Greenaway Simon, Hewitt Mazda, McCormick Stefan, Selley Rachael, Wells Christine, Tymowska-Lalanne Zuzanna, Roby Phil, Mburu Philomena, Rogers Derek, Hagan Jim, Reavill Charlie, Davies Kay, Glenister Peter, Fisher Elizabeth M C, Martin Josephine, Vizor Lucy, Bouzyk Mark, Kelsell David, Guenet J L, Steel Karen P, Sheardown Steve, Spurr Nigel, Gray Ian, Peters Jo, Nolan Patrick M, Hunter A Jacqueline, Brown Steve D M
Abstract excerpt
With the completion of the first draft of the human genome sequence, the next major challenge is assigning function to genes. One approach is genome-wide random chemical mutagenesis, followed by screening for mutant phenotypes of interest and subsequent mapping and identification of the mutated genes in question. We (a consortium made up of GlaxoSmithKline, the MRC Mammalian Genetics Unit and Mouse Genome Centre,...
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