Article
Risk of wrist fracture in women is heritable and is influenced by genes that are largely independent of those influencing BMD.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 2005
Andrew Toby, Antioniades Leto, Scurrah Katrina J, Macgregor Alex J, Spector Tim D
Abstract excerpt
UNLABELLED: Using a classical twin design study, we estimated the genetic contribution to liability of wrist fracture in women to be statistically and clinically significant. BMD is highly heritable, but statistical models showed very little overlap of shared genes between the two traits. INTRODUCTION: Studies have observed contradictory evidence for genetic effects influencing the outcome of osteoporotic...
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