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Article

The genetic influence on radiographic osteoarthritis is site specific at the hand, hip and knee.

Rheumatology (Oxford, England) - 1 Mar 2009

MacGregor A J, Li Q, Spector T D, Williams F M K

Abstract excerpt

OBJECTIVE: To identify whether a shared genetic influence accounts for the occurrence of OA at different skeletal sites. METHODS: Multivariate modelling of data on prevalent radiographic OA at the hand (DIP, PIP and CMC joints), hip and knee joints assessed in 992 monozygotic and dizygotic female twin participants from the TwinsUK Registry. RESULTS: OA at all the five joint sites was heritable. Genetic influences...

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Identifiers

PMID: 19153142
DOI: 10.1093/rheumatology/ken475
PMCID: PMC2644047

Genes

PIP

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