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Article

Side chain and backbone contributions of Phe508 to CFTR folding.

Nature structural & molecular biology - 1 Jan 2005

Thibodeau Patrick H, Brautigam Chad A, Machius Mischa, Thomas Philip J

Abstract excerpt

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), an integral membrane protein, cause cystic fibrosis (CF). The most common CF-causing mutant, deletion of Phe508, fails to properly fold. To elucidate the role Phe508 plays in the folding of CFTR, missense mutations at this position were generated. Only one missense mutation had a pronounced effect on the stability and folding of the...

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Identifiers

PMID: 15619636
DOI: 10.1038/nsmb881
PMCID: PMC3516198

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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